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مقاله
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Abstract
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Title:
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Association of Polymorphisms of Complement factor I rs141853578 (G119R) with Age-Related Macular Degeneration In an Iranian Population
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Author(s):
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Mortaza Bonyadi1,2 ,PhD; Neda Norouzi1 , Msc; Esmaeil Babaei1 ,Msc; Mohammad Hossein Jabbarpoor Bonyadi3,MD; Alireza Javadzadeh4 ,MD; Mehdi Yaseri5 ,PhD; Masoud Soheilian3,MD.
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Presentation Type:
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Oral
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Subject:
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Posterior Segment
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Others:
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Presenting Author:
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Name:
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Mohammadhossein Jabbarpourbonyadi
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Affiliation :(optional)
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ophthalmic research center
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E mail:
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mhbonyadi@yahoo.com
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Phone:
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Mobile:
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09144170912
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Purpose:
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Complement factor I regulates the complement pathways and relationship between CFI polymorphisms and AMD is controversial. We evaluated the possible association of complement factor I rs141853578 (G119R) variation with advanced AMD in Iranian patients.
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Methods:
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We included 371 case-control samples consisting of 220 advanced type AMD patients and 151 genetically unrelated healthy controls enrolled for evaluation. Extracted-DNA samples amplified to obtain fragment including the polymorphic region complement factor I rs141853578 (G119R).
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Results:
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The distribution of the genotypes was significantly different in the AMD patients compared to that of controls (p=0.035). The TT genotype frequencies for CFI was significantly higher in AMD group (7.7% vs 2%, OR=4.67, CI=1.33-16.45, p=0.016(. This significant effect was maintained after adjustment for the effects of age and gender (OR=5.09, CI= 1.42-18.20, p=0.012). The minor allele frequency was also significantly higher in AMD patients than in controls (29.3% vs 21.5% OR 1.51, CI 1.07-2.13, p=0.018).
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Conclusion:
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Our study showed strong risk effect of CFI rs141853578 (G119R) in advanced type AMD. Present data suggests that this locus polymorphism is not as rare in our studied population as previously reported from different population.
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Attachment:
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