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مقاله
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Abstract
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Title:
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The effect of topical 2% cyclosporine for the treatment of acute anterior uveitis: Is there a place for topical cyclosporine in uveitis?
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Author(s):
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Seyedeh Maryam Hosseini, MD; Mohammad Arjmand, MD; Mir-naghi Mousavi, MD; Negar Morovatdar, MD; Mehdi Ghasemi, MD
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Presentation Type:
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Oral
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Subject:
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Uveitis
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Others:
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Presenting Author:
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Name:
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Seyedeh Maryam Hosseini
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Affiliation :(optional)
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Eye research center,Mashhad University of Medical Sciences
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E mail:
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smaryam_hosseini@yahoo.com
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Phone:
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05137281401
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Mobile:
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09153172911
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Purpose:
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To evaluate the synergistic effects of topical 2% cyclosporine for the treatment of acute anterior uveitis.
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Methods:
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In this randomized, double-blind clinical trial, patients with a first attack of unilateral acute non-granulomatous, non-infectious anterior uveitis were randomly assigned to receive either topical 2% cyclosporine (group A) or placebo (group B), both in association with topical 1% prednisolone. The primary outcome measured was the average time to resolution of inflammation (anterior chamber cells <0.5+).
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Results:
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Sixty eyes of 60 patients were divided into two equal groups. Resolution of inflammation in group A (21.3 days) was significantly faster than in group B (25.4 days; p=0.004). The average prednisone dosage used in group A (129.76 drops) was significantly lower than that in group B (164.6 drops; p=0.0001). Moreover, the average increase in intraocular pressure was significantly lower in group A (p<0.05) than group B.
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Conclusion:
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Topical 2% cyclosporine could be considered as an adjunct to topical corticosteroids for reducing the dosage of topical corticosteroids for the treatment of acute non-granulomatous, non-infectious anterior uveitis.
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Attachment:
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