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       XXVII Annual Congress of the Iranian Society of Ophthalmology        بـیــست و هفتمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران
مقاله Abstract


Title: Pattern of Peripapillary Capillary Density Loss in Ischemic Optic Neuropathy Compared to that in Primary Open-Angle Glaucoma
Author(s): Sasan moghimi, Masoud Aghsaei Fard
Presentation Type: Oral
Subject: Strabismus & Neuro-ophthalmology
Others:
Presenting Author:
Name: Masood Aghsaie fard
Affiliation :(optional) Farabi Eye Hospital
E mail: masood219@gmail.com
Phone: 4794177
Mobile: 09127934689
Purpose:

Both non-arteritic anterior ischemic optic neuropathy (NAION) and primary open-angle glaucoma (POAG) damage retinal ganglion cell axons, which are perfused by the radial peripapillary capillaries. To evaluate the pattern of ischemia, we compared peripapillary capillary density (PCD) in NAION eyes to POAG eyes matched for visual field mean deviation and retinal nerve fiber layer thickness.

Methods:

31 chronic NAION (>6 months after acute event) and unaffected fellow eyes (31 subjects), 42 moderate and severe POAG eyes (27 subjects), and 77 control eyes (46 healthy subjects) were imaged on a commercial optical coherence tomography angiography system (AngioVue, Avanti RTVue-XR, Optovue, CA) at two academic institutions. Two concentric circles of diameters 1.95mm (inner) and 3.45mm (outer) were manually placed on images centered on the optic nerve head, producing an annular region-of-interest. Image analysis with major vessel removal was performed using a custom program. Whole-image, whole-annulus, and sectoral PCDs were measured.

Results:

Whole-image and whole-annulus PCDs in NAION and moderate and severe POAG eyes were significantly decreased compared to unaffected fellow eyes and control eyes (all P<0.001). Superior and temporal PCD values were affected more than other sectors in both NAION and POAG groups compared to control group. Wholeimage and whole-annulus PCDs were not statistically different between NAION and POAG eyes (both P=0.99). However, of all peripapillary sectors, inferior sector PCD value was less affected in POAG eyes compared to NAION eyes (P=0.001). Univariate analysis results also revealed a significant positive correlation between superior and inferior PCDs and corresponding RNFL thicknesses. Those correlations were greater in POAG than NAION eyes.

Conclusion:

While the whole PCD were not different in chronic NAION and POAG, the greater correlation of PCD with corresponding RNFL sectors in POAG compared to NAION suggests greater contribution of radial peripapillary capillary in the pathogenesis of POAG.

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