|
مقاله
|
Abstract
|
|
|
Title:
|
Pattern of Peripapillary Capillary Density Loss in Ischemic Optic Neuropathy Compared to that in Primary Open-Angle Glaucoma
|
Author(s):
|
Sasan moghimi, Masoud Aghsaei Fard
|
Presentation Type:
|
Oral
|
Subject:
|
Strabismus & Neuro-ophthalmology
|
Others:
|
|
Presenting Author:
|
|
Name:
|
Masood Aghsaie fard
|
Affiliation :(optional)
|
Farabi Eye Hospital
|
E mail:
|
masood219@gmail.com
|
Phone:
|
4794177
|
Mobile:
|
09127934689
|
|
|
Purpose:
|
Both non-arteritic anterior ischemic optic neuropathy (NAION) and primary
open-angle glaucoma (POAG) damage retinal ganglion cell axons, which are perfused
by the radial peripapillary capillaries. To evaluate the pattern of ischemia, we
compared peripapillary capillary density (PCD) in NAION eyes to POAG eyes matched
for visual field mean deviation and retinal nerve fiber layer thickness.
|
Methods:
|
31 chronic NAION (>6 months after acute event) and unaffected fellow eyes
(31 subjects), 42 moderate and severe POAG eyes (27 subjects), and 77 control eyes
(46 healthy subjects) were imaged on a commercial optical coherence tomography
angiography system (AngioVue, Avanti RTVue-XR, Optovue, CA) at two academic
institutions. Two concentric circles of diameters 1.95mm (inner) and 3.45mm (outer)
were manually placed on images centered on the optic nerve head, producing an
annular region-of-interest. Image analysis with major vessel removal was performed
using a custom program. Whole-image, whole-annulus, and sectoral PCDs were
measured.
|
Results:
|
Whole-image and whole-annulus PCDs in NAION and moderate and severe
POAG eyes were significantly decreased compared to unaffected fellow eyes and
control eyes (all P<0.001). Superior and temporal PCD values were affected more than
other sectors in both NAION and POAG groups compared to control group. Wholeimage
and whole-annulus PCDs were not statistically different between NAION and
POAG eyes (both P=0.99). However, of all peripapillary sectors, inferior sector PCD
value was less affected in POAG eyes compared to NAION eyes (P=0.001). Univariate
analysis results also revealed a significant positive correlation between superior and
inferior PCDs and corresponding RNFL thicknesses. Those correlations were greater
in POAG than NAION eyes.
|
Conclusion:
|
While the whole PCD were not different in chronic NAION and POAG, the
greater correlation of PCD with corresponding RNFL sectors in POAG compared to
NAION suggests greater contribution of radial peripapillary capillary in the
pathogenesis of POAG.
|
Attachment:
|
|
|
|