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       XXVII Annual Congress of the Iranian Society of Ophthalmology        بـیــست و هفتمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران
مقاله Abstract


Title: Effect of sildenafil (phosphodisterase 5 inhibitors) on the development of retinopathy of prematurity: A Randomized Clinical Trial
Author(s): Masood Dehdashtian-Mostafa Feghhi-Mohammadreza Aramesh-Arash Malekian-Mohammadreza Abaspoor-Mohammasd hasan Altayeb-Ali Khosravi
Presentation Type: Oral
Subject: Posterior Segment
Others:
Presenting Author:
Name: Mostafa Feghhi
Affiliation :(optional) Ahvaz Jundishapur Medical Seince University
E mail: feghhim671@live.com
Phone: 061-33378740
Mobile: 09161183228
Purpose:

Retinopathy of Prematurity(ROP) is a major cause of blindness in premature newborns worldwide. Hyperoxia is one of the most important risk factors in the development of ROP. Hyperoxia leads to suppression of Hypoxia-Inducible Factor (HIF)-1 and vascular endothelial growth factor (VEGF), which in turn causes both cessation of retinal vessel growth and loss of some existing retinal vessels (phase 1 ROP). We hypothesized that inhibition of Phosphodiesterase 5 enzyme suppress retinal vasoconstriction secondary to hyperoxia and prevent ROP phase 1 and subsequently ROP phase 2

Methods:

0ne hundred newborns with respiratory distress syndrome treated with oxygen were randomized into two groups as Group A, Placebo (as control group) and Group B (intervention group), sildenafil were administered via nasogastric tube. Occurrence of ROP phase 1 as primary outcome and stage 2-5 ROP, duration of mechanical ventilation, Nasal Continuous Positive Airway Pressure (NCPAP), oxygen therapy and duration of hospitalization as secondary outcomes were assessed

Results:

Fifty patients in each group were studied. ROP phase 1 was seen in 11(22%) and 7(14%) of placebo and interventional group, respectively

Conclusion:

The current study showed that sildenafil might prevent neovascularization in premature infants.

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