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مقاله
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Abstract
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Title:
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Treatment of Epidemic Keratoconjunctivitis with a Combination of Povidone-Iodine drops: A Controlled Randomized Study
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Author(s):
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Mohammad Hossein Validad, Gholamreza Seyedpiran, Seyed Sajad Ahmadi, Omid Bagherzadeh, Keyvan Behkam Rad, Hamideh Sabbaghi
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Presentation Type:
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Oral
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Subject:
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Cornea and Anterior Segment
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Others:
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Presenting Author:
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Name:
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Hamideh Sabbaghi
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Affiliation :(optional)
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Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran
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E mail:
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sabbaghi_h@yahoo.com
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Phone:
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02122808857
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Mobile:
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09120285930
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Purpose:
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To investigate the therapeutic effect of topical povidone-iodine (PVP-I) in patients suffering from EKC under the controlled study condition.
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Methods:
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In this double masked randomized clinical trial, a total of 60 patients with EKC and a mean age of 27.8±12.4 years old were examined at Alzahra Eye Hospital, Zahedan, Iran. The study population were classified into the three groups in which 20 patients were investigated. Cases in group I were received PVP-I drop 0.4%, betamethasone drop 0.1 %, and artificial tear drop and cases in group II were installed PVP-I drop 0.2%, betamethasone drop 0.1%, and artificial tear drop. In addition, controls in group III were received betamethasone drop 0.1%, artificial tear drop, and chloramphenicol drop. Conjunctival injection and discharge, chemosis, periorbital edema, hemorrhage and sub-epithelial opacity were recorded. Comprehensive examinations were performed at baseline and at 4, 7 and 10 days after the treatment.
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Results:
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Statistical analysis reveals that infectious discharges in groups with a history of PVP-I usage were less and they were being recovered more and faster compared to the control group (P=0.001, P=0.004). In addition, there was a higher amount of sub-epithelial opacity in the groups using PVP-I (group I, 30%, group II, 20% vs. group III, 10%). There was not any statistically significant difference regarding other recorded outcomes among the three study groups.
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Conclusion:
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Based on our findings, PVP-I could be effective in the fast treatment of EKC. The prescription of PVP-I seems to be challenging due to the induced sub-epithelial opacity after the treatment.
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Attachment:
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