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مقاله
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Abstract
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Title:
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One-year results of a trial comparing two doses of intravitreal ziv-aflibercept vs bevacizumab for treatment of diabetic macular edema
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Author(s):
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Mohammad Hossein Jabbarpoor Bonyadi , Ahmadreza Baghi, Alireza Ramezani, Mehdi Yaseri, Masoud Soheilian.
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Presentation Type:
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Oral
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Subject:
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Posterior Segment
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Others:
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Presenting Author:
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Name:
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Mohammadhossein Jabbarpourbonyadi
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Affiliation :(optional)
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ophthalmic research center
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E mail:
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mhbonyadi@yahoo.com
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Phone:
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Mobile:
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09144170912
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Purpose:
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To report one year findings of trial comparing two doses of intravitreal ziv-aflibercept (IVZ) with intravitreal bevacizumab (IVB) for treatment of center-involving diabetic macular edema (DME).
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Methods:
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In this clinical trial, eyes with DME were randomly assigned to 2.5mg intravitreal ziv-aflibercept (42 eyes), 1.25mg intravitreal ziv-aflibercept (42 eyes), and 1.25mg IVB injections (39 eyes), every 4 weeks for 3 loading injections and then every 4 weeks for IVB and every 8 weeks for ziv-aflibercept injections. The patients were followed up to 1 year with complete ophthalmologic examination and central macular thickness (CMT) measurement by optical coherence tomography.
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Results:
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While no significant difference was evident between two ziv-aflibercept groups at 1 year, best-corrected visual acuity (BCVA) change was significantly better in both ziv-aflibercept groups than the IVB group at final follow-up (P=0.007 for IVZ 2.5 mg and P=0.029 for IVZ 1.25 mg). Regarding CMT changes, there was no significant difference between two ziv-aflibercept groups; however, a significantly more reduction in CMT was observed in the ziv-aflibercept 2.5mg group in comparison to the IVB group at 1 year (P=0.029). Subgroup analysis disclosed no difference in BCVA outcomes at 1 year among the eyes with baseline BCVA >20/50 in ziv-aflibercept groups compared to the IVB group. In the eyes with baseline BCVA ≤20/50 nonetheless, the improvement was significantly better at 1 year in both ziv-aflibercept groups compared to the IVB group (P=0.002 for IVZ 2. 5 mg and P=0.001 for IVZ 1.25 mg).
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Conclusion:
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The 1-year results of this trial disclosed more vision improvement of intravitreal ziv-aflibercept compared to intravitreal bevacizumab in the treatment of center-involving DME. This stronger effect of intravitreal ziv-aflibercept however, was detected in the eyes with initial worse level of vision (≤20/50).
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Attachment:
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