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       XXVII Annual Congress of the Iranian Society of Ophthalmology        بـیــست و هفتمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران
مقاله Abstract


Title: Various retinal vascular manifestations of neurofibromatosis-1 in a single patient
Author(s): Meisam Ghanbari
Presentation Type: Poster
Subject: Posterior Segment
Others:
Presenting Author:
Name: Meisam Ghanbari
Affiliation :(optional) Department of ophthalmology , Shiraz university of medical sciences
E mail: meisam.ghanbari@gmail.com
Phone: 09127336271
Mobile: 09127336271
Purpose:

To report an Iranian woman with a variety of retinal vascular manifestations secondary to neurofibromatosis -1.

Methods:

A 49 years old woman presented with a long history of decreased vision in her right eye worsening recently. The patient was a known case of neurofibromatosis-1 (NF-1). General medical exam showed signs of neurofibromatosis and was otherwise normal. We found peculiar retinal and choroidal findings.

Results:

On fundus examination of the right eye, mild vascular tortuosity and few hard exudates were the prominent finding; however, left eye showed temporal disc pallor, localized saccular dilatation of inferior hemiretinal artery at its 1st bifurcation typical of arterial macroaneurysm, attenuation of the vessels and a distal embolus occluding the successive branching. Fluorescein angiography, revealed multiple bright choroidal nodules in both eyes. Left eye showed hyperfluorescence and leakage at the site of localized saccular dilatation in inferotemporal quadrant and filling defects in both arteries and veins of the same quadrant in favor of branch retinal artery occlusion and branch retinal vein occlusion, respectively. Multiple areas of capillary non perfusion areas were seen in both eyes.

Conclusion:

As vascular and microvascular manifestations of NF-1 are being reported recently, further investigational studies for retinal vascular associations in NF-1 patients appears reasonable. Complete ophthalmic examinations in each NF-1 patient seems essential to prevent potential threatening complications of vascular events in these patients.

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