To describe outcomes of Trabectome surgery in a large cohort with various glaucoma subtypes over 12 months period.

Data from 2,278 glaucoma patients who underwent the Trabectome procedure were analyzed. The subjects were divided into the following glaucoma subcategories: primary open angle glaucoma (POAG), pseudoexfoliative glaucoma (PEXG), uveitic glaucoma, steroid-induced glaucoma (SIG), normal tension glaucoma (NTG), ocular hypertension (OHTN), pigmentary and traumatic glaucoma. Wilcoxon test were conducted for detecting reduction of IOP and number of glaucoma medications. Kaplan-Meier analysis was used for survival analysis with success defined as IOP≤21 mmHg, at least 20% IOP reduction from baseline after 3 months for any 2 consecutive visits and no additional glaucoma surgery.

A total of 2278 glaucoma patients averaging 69 years old (range: 0-96) showed IOP reduction from 23.4±7.8 mmHg at baseline to 15.9±4.0 mmHg at 12 months (p<0.01), while the number of glaucoma medications was reduced from 2.7±1.3 at baseline to 2.0±1.4 at 12 months (p<0.01). The 12-month success rate of the overall group was 88%. The greatest efficacy and success rate in PEXG, SIG, and POAG. It was less effective in cases with NTG.

Trabectome demonstrated success in reducing both IOP and the number of medications on a wide range of glaucoma conditions; however, proper case selection is important to achieve good surgical results.