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       XXVII Annual Congress of the Iranian Society of Ophthalmology        بـیــست و هفتمین کنــگــره سـالیـانه انـجـمـن چـشـم پـزشـکی ایـــران
مقاله Abstract


Title: Topiramate and the vision: updated systematic review 2017
Author(s): Mohammad-Ali Abtahi, Sara Ghafari, Hamidreza Jahanbani-Ardakani, Seyed-Hossein Abtahi
Presentation Type: Poster
Subject: Strabismus & Neuro-ophthalmology
Others:
Presenting Author:
Name: Hamidreza Jahanbani Ardakani
Affiliation :(optional) Department of ophthalmology, Feiz Eye Hospital, Isfahan University of Medical Sciences, Isfahan, Iran
E mail: hamidreza_jahanbaniardakani@yahoo.com
Phone:
Mobile: 09390216839
Purpose:

Topiramate (TPM) is a sulfa derived monosaccharide, administered for wide range of diseases such as migraine, epilepsy, trigeminal neuralgia, bipolar disorders, cluster headache etc. Ophthalmological side effects of TPM are one of the crucial issued and until now, many cases with TPM-induced ciliochoroidal effusion syndrome and other adverse effects have been reported. In this systematic review, the aim was to provide a systematic literature review regarding this issue.

Methods:

For the literature review process, a complete search was performed in PubMed and web of science data bases from 1996 to August 2017. Overall, 820 citations were examined for inclusion. Furthermore, available data of patients with TPM-induced angle closure glaucoma (TiACG) and TPM-induced myopic shift (TiMS) were analyzed.

Results:

A total of 146 cases with TPM induced ophthalmologic side effects were included. 68 and 27 patients with TiACG and TiMS were found. Mean age of patients with TiACG and TiMS were 38.51±12.67 and 29.21±11.12 respectively. furthermore, more than 80 percent of patients experienced TiACG or TiMS during first two weeks of TPM administration or changing TPM dosage. In our analysis, we did not find any correlation between TPM dosage and values of intra-ocular pressure or myopic shift (P>0.05).

Conclusion:

As TPM administration has wide spectrum of indications, neurologists as well as psychiatrics should be aware of TPM ophthalmic complications. In addition, early diagnosis of TiACG and TiMS could result to complete recovery and replacing TPM with another drug is necessary.

Attachment: 142Topiramate.pptx





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